Monas 1010 mg Tablet Montelukast

Antibodies to leukotriene receptors

The arachidonic acid metabolism results in the production of cysteinyl leukotrienes (LTC4, LTD4, and LTE4) from a variety of cells, including mast cells and eosinophils. Cysteinyl leukotriene receptors (CysLT) are located in the human airway, and these eicosanoids bind to them. The orally active drug Monas 10 10 mg has a strong affinity and specificity for the CysLT1 receptor. Without any agonist activity, it inhibits LTD4's physiological effects at the CysLT1 receptor.

In the prevention and long-term treatment of asthma, Monas 10 10 mg has been provided alongside other commonly used treatments without seeming to increase the risk of negative side effects. According to studies on drug interactions, theophylline, prednisone, prednisolone, oral contraceptives (norethindrone 1mg/ethinyl estradiol 35mcg), terfenadine, digoxin, and warfarin did not exhibit any clinically significant effects on the pharmacokinetics at the recommended clinical dose of it. In clinical investigations, the medication was used concurrently with a variety of routinely prescribed medications without showing any signs of clinically harmful interactions, despite the fact that more detailed interaction studies were not carried out. Thyroid hormones, hypnotic sedatives, benzodiazepines, non-steroidal anti-inflammatory drugs, and decongestants were among these drugs. Following a single dose of this solution, the hepatic metabolism-inducing drug phenobarbital reduced the drug's AUC by about 40%. For this medication, no dosage modification is advised. When powerful cytochrome P450 enzyme inducers, such as phenobarbital or rifampin, are provided alongside this solution, it is fair to use proper clinical monitoring.

Those who have an extreme sensitivity to any ingredient in this medication should not take it.

Common: upper respiratory tract infection, diarrhea, fever, gastrointestinal pain, headache, nausea, and vomiting. The following symptoms are uncommon: akathisia, anxiety, arthralgia, asthenia, aberrant behavior, depression, dizziness, drowsiness, dry mouth, hemorrhage, irritability, malaise, muscle complaints, oedema, seizure, odd feeling, and sleep disturbances. Rare: Pulmonary eosinophilia, angioedema, decreased attention, disorientation, erythema nodosum, hallucinations, hepatic problems, memory loss, palpitations, suicidal thoughts, and tremor.

Monas 10 10 mg is classified as pregnancy category B. Although it has been demonstrated that the medication crosses the placenta of pregnant rats and rabbits, there are no records of its use in pregnant humans. Although there is some evidence that it is also secreted in breast milk, little is known about the implications of this discovery. Before starting the therapy in nursing moms, caution should be exercised.